Dr. Rose C Tanui

Designation: Lecturer
School/Institute: Science
Email address: rose.tanui@dkut.ac.ke

Academic Background

  Qualification   Institution  Year
 Ph.D., Biophysical Chemistry  Binghamton University, State University of New York,  August 2016
 B.Sc., Biochemistry and Botany  The University of Nairobi, Kenya  October 2008

Peer-reviewed Publications:

  1. Kurnvir S., Tanui R., Gameiro A., Eisenberg G., Schlessinger A., Grewer C. Structure activity relationships of benzyl proline-derived inhibitors of the glutamine transporter ASCT2. 2016. In Press.
  2. Tanui R., Tao Z., Grewer C. Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1. Journal of Biological Chemistry 2016; 291(22):11852-64
  3. Rauen T., Tanui R., Grewer C. Structural and functional dynamics of Excitatory Amino Acid Transporters (EAAT). AIMS molecular science, 2014, 1(3): 99-125.

Current Research Interest:

  • Chemistry of Membrane Transporters
  • Electrophysiology
  • Neurochemistry

Skills:

  • Expert in Patch-clamping technique
  • Graduate and Undergraduate mentor
  • Electrophysiology techniques
  • Origin analysis package
  • Molecular biology
  • Cell culturing

Affiliations and Awards:

  • Summer Research Fellowship Awards, Binghamton University, 2010-2013.
  • American Chemical Society, Member, Biophysical Division, 2011-present

Dissertation project: Glutamate Transporters of the Central Nervous System

For my PhD dissertation, I worked on research aimed at understanding the structure and function of membrane transporters. I focused on glutamate (a neurotransmitter) transporters because studies have shown that they are responsible for many known neurological disorders like the Alzheimer’s disease and stroke. I used human embryonic kidney cells under physiological conditions to study the effect of different ionic conditions and varying membrane voltages on the glutamate transport process. My research led to the establishment of one previously unknown Electrogenic step in the process of glutamate transport, a fundamental step in understanding the transport of this important neurotransmitter.